Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
caushy_pd Exclusive	gp2	4.58e-01	3.44e-01	1.15e-03	4.00e-04
gp2 Exclusive	caushy_pd	1.82e-01	1.03e-01	1.26e-26	6.11e-16
caushy_pd Exclusive	gp2 Exclusive	4.23e-01	3.54e-01	6.93e-03	1.60e-03
gp2 Exclusive	caushy_pd Exclusive	1.78e-01	1.08e-01	1.70e-29	4.46e-15
caushy_pd Exclusive	Overlap	4.16e-01	9.31e-01	7.92e-02	1.19e-01
gp2 Exclusive	Overlap	7.92e-02	1.98e-02	3.96e-02	7.92e-02
Overlap	Exclusives	1.96e-02	8.54e-02	3.36e-32	3.89e-14



Evaluating how well caushy_pd genes are linked to gp2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_pd Exclusive	gp2	0.87	2.88	2.76	2.58	4.61
gp2 Exclusive	caushy_pd	0.69	3.15	3.01	1.97	9.42
caushy_pd Exclusive	gp2 Exclusive	0.87	3.49	3.22	2.63	3.91
gp2 Exclusive	caushy_pd Exclusive	0.69	2.82	2.95	2.41	7.86
caushy_pd Exclusive	Overlap	0.90	-1.00	0.19	0.85	1.50
gp2 Exclusive	Overlap	0.98	1.95	1.89	2.15	1.66
Overlap	Exclusives	0.68	1.13	1.86	1.94	8.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
caushy_pd Exclusive	gp2	0.00	0.50	-7.29	3.16	3.50
gp2 Exclusive	caushy_pd	0.02	3.17	3.94	3.57	5.46
caushy_pd Exclusive	gp2 Exclusive	0.00	0.52	-10.30	1.94	4.17
gp2 Exclusive	caushy_pd Exclusive	0.02	3.07	3.52	3.94	6.19
caushy_pd Exclusive	Overlap	0.00	-0.73	-0.47	0.09	1.91
gp2 Exclusive	Overlap	0.00	2.94	8.98	2.69	-0.06
Overlap	Exclusives	0.02	0.71	0.68	1.33	4.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
caushy_pd Exclusive	160	160	
gp2 Exclusive	9	8	GBNMP
Overlap	1	1