Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_PD_wo_wavelet Exclusive	gp2union	1.22e-01	3.62e-02	3.21e-02	1.10e-04
gp2union Exclusive	fcs_PD_wo_wavelet	3.80e-02	7.67e-03	4.91e-25	2.29e-04
fcs_PD_wo_wavelet Exclusive	gp2union Exclusive	7.14e-02	1.01e-02	1.66e-02	3.28e-04
gp2union Exclusive	fcs_PD_wo_wavelet Exclusive	7.30e-02	2.06e-02	5.44e-25	4.86e-04
fcs_PD_wo_wavelet Exclusive	Overlap	1.99e-01	1.02e-01	6.21e-02	1.80e-01
gp2union Exclusive	Overlap	9.85e-05	9.85e-05	5.91e-04	9.85e-05
Overlap	Exclusives	1.00e-06	3.53e-03	6.17e-01	8.47e-06



Evaluating how well fcs_PD_wo_wavelet genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD_wo_wavelet Exclusive	gp2union	0.83	1.95	3.56	2.45	4.12
gp2union Exclusive	fcs_PD_wo_wavelet	0.60	2.97	3.32	2.31	5.13
fcs_PD_wo_wavelet Exclusive	gp2union Exclusive	0.84	1.65	3.16	2.16	4.91
gp2union Exclusive	fcs_PD_wo_wavelet Exclusive	0.60	2.31	2.76	2.07	5.19
fcs_PD_wo_wavelet Exclusive	Overlap	0.77	1.91	1.70	1.81	1.36
gp2union Exclusive	Overlap	1.00	9.15	3.68	4.63	2.35
Overlap	Exclusives	0.61	1.84	3.16	1.71	4.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_PD_wo_wavelet Exclusive	gp2union	0.00	1.61	0.15	2.90	0.51
gp2union Exclusive	fcs_PD_wo_wavelet	0.02	7.48	7.09	5.12	8.27
fcs_PD_wo_wavelet Exclusive	gp2union Exclusive	0.01	1.20	-0.02	4.18	7.49
gp2union Exclusive	fcs_PD_wo_wavelet Exclusive	0.02	4.11	4.47	3.70	7.50
fcs_PD_wo_wavelet Exclusive	Overlap	0.00	0.10	-0.16	0.02	0.01
gp2union Exclusive	Overlap	0.09	521.24	302.25	19.17	542.59
Overlap	Exclusives	0.02	4.09	8.55	4.28	6.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_PD_wo_wavelet Exclusive	194	194	
gp2union Exclusive	14	13	GBNMP
Overlap	2	2