Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	singleton	1.43e-02	3.75e-04	6.38e-05	1.36e-09
singleton	GeneGroup1	8.29e-02	1.35e-01	3.30e-16	9.25e-04



Evaluating how well GeneGroup1 genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	singleton	0.88	2.89	4.44	3.41	6.10
singleton	GeneGroup1	0.58	2.03	2.25	1.59	4.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	singleton	0.01	1.42	2.97	3.46	15.41
singleton	GeneGroup1	0.02	8.16	4.76	6.12	6.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	196	196	
singleton	21	21