Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_wo_wavelet	gp2_union	3.82e-01	5.05e-01	5.59e-01	1.03e-02
gp2_union	2mcs_wo_wavelet	4.86e-01	8.63e-01	1.08e-08	4.65e-01



Evaluating how well 2mcs_wo_wavelet genes are linked to gp2_union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_wo_wavelet	gp2_union	0.69	0.22	0.57	0.46	2.42
gp2_union	2mcs_wo_wavelet	0.52	-0.14	0.14	0.59	0.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_wo_wavelet	gp2_union	0.00	-0.39	-0.34	-0.17	0.44
gp2_union	2mcs_wo_wavelet	0.00	0.05	-0.09	0.44	0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_wo_wavelet	81	81	
gp2_union	16	15	GBNMP