Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
2mcs_wo_wavelet	singleton	7.60e-01	7.10e-01	8.53e-01	3.97e-03
singleton	2mcs_wo_wavelet	1.23e-01	8.82e-01	8.08e-07	9.04e-01



Evaluating how well 2mcs_wo_wavelet genes are linked to singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_wo_wavelet	singleton	0.69	0.57	0.47	0.17	3.14
singleton	2mcs_wo_wavelet	0.51	-0.23	-0.22	0.18	0.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
2mcs_wo_wavelet	singleton	0.00	-0.18	-0.43	-0.42	0.56
singleton	2mcs_wo_wavelet	0.00	0.01	-0.28	0.05	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
2mcs_wo_wavelet	81	81	
singleton	21	21