Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cauchy_wo_78	gp2union	2.46e-01	2.31e-01	2.26e-01	4.34e-03
gp2union	cauchy_wo_78	9.41e-01	9.72e-01	3.12e-07	4.89e-01



Evaluating how well cauchy_wo_78 genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cauchy_wo_78	gp2union	0.75	1.41	2.06	1.56	3.47
gp2union	cauchy_wo_78	0.52	0.47	0.24	0.73	0.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cauchy_wo_78	gp2union	0.00	1.30	3.08	1.61	3.54
gp2union	cauchy_wo_78	0.01	2.65	1.78	2.23	1.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cauchy_wo_78	78	78	
gp2union	16	15	GBNMP