Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
cauchy_wo_wav_177 Exclusive	gp2union	4.60e-01	1.79e-01	6.68e-01	1.11e-03
gp2union Exclusive	cauchy_wo_wav_177	4.08e-01	3.83e-01	8.95e-18	8.76e-01
cauchy_wo_wav_177 Exclusive	gp2union Exclusive	5.53e-01	3.64e-01	9.52e-01	2.98e-03
gp2union Exclusive	cauchy_wo_wav_177 Exclusive	4.80e-01	5.80e-01	1.34e-16	9.48e-01
cauchy_wo_wav_177 Exclusive	Overlap	1.19e-01	1.98e-01	1.78e-01	3.56e-01
gp2union Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.39e-03	2.58e-02	9.05e-09	4.83e-02



Evaluating how well cauchy_wo_wav_177 genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cauchy_wo_wav_177 Exclusive	gp2union	0.76	1.36	2.42	1.52	3.45
gp2union Exclusive	cauchy_wo_wav_177	0.50	1.47	1.35	1.06	-0.06
cauchy_wo_wav_177 Exclusive	gp2union Exclusive	0.75	0.82	1.94	0.72	3.07
gp2union Exclusive	cauchy_wo_wav_177 Exclusive	0.50	1.17	0.91	0.72	-0.10
cauchy_wo_wav_177 Exclusive	Overlap	0.84	1.98	1.96	2.11	1.13
gp2union Exclusive	Overlap	1.00	31.89	5.83	3.98	1.76
Overlap	Exclusives	0.55	1.52	2.97	1.78	2.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
cauchy_wo_wav_177 Exclusive	gp2union	0.00	0.77	0.19	0.44	0.32
gp2union Exclusive	cauchy_wo_wav_177	0.01	2.80	3.40	1.78	1.26
cauchy_wo_wav_177 Exclusive	gp2union Exclusive	0.00	0.49	0.24	0.03	1.76
gp2union Exclusive	cauchy_wo_wav_177 Exclusive	0.01	0.91	0.64	0.31	-0.12
cauchy_wo_wav_177 Exclusive	Overlap	0.00	0.04	0.18	0.37	-0.11
gp2union Exclusive	Overlap	0.17	180925.39	717.73	205.79	192.17
Overlap	Exclusives	0.02	6.74	12.96	7.98	10.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
cauchy_wo_wav_177 Exclusive	176	175	AC010255.3
gp2union Exclusive	15	14	GBNMP
Overlap	1	1