Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-familial	2.71e-22	1.38e-15	3.23e-33	4.11e-29
BRCA-familial Exclusive	BRCA_ReactomeCoreGenes_atleast8	7.12e-11	1.64e-09	3.63e-37	2.27e-24
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-familial Exclusive	5.15e-11	4.37e-07	5.53e-18	4.62e-18
BRCA-familial Exclusive	BRCA_ReactomeCoreGenes_atleast8 Exclusive	8.69e-08	1.31e-08	3.35e-33	2.23e-23
BRCA_ReactomeCoreGenes_atleast8 Exclusive	Overlap	1.78e-21	1.78e-21	1.78e-21	8.87e-16
BRCA-familial Exclusive	Overlap	1.78e-21	1.78e-21	1.78e-21	1.78e-20
Overlap	Exclusives	1.49e-12	1.79e-10	7.90e-27	6.24e-25



Evaluating how well BRCA_ReactomeCoreGenes_atleast8 genes are linked to BRCA-familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-familial	0.99	3.36	7.00	3.07	8.09
BRCA-familial Exclusive	BRCA_ReactomeCoreGenes_atleast8	0.75	2.60	8.34	3.28	13.62
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-familial Exclusive	0.99	3.13	4.81	3.07	6.18
BRCA-familial Exclusive	BRCA_ReactomeCoreGenes_atleast8 Exclusive	0.74	2.40	7.38	3.17	12.43
BRCA_ReactomeCoreGenes_atleast8 Exclusive	Overlap	1.00	2.96	4.97	2.69	5.63
BRCA-familial Exclusive	Overlap	1.00	2.24	4.65	2.87	5.31
Overlap	Exclusives	0.75	3.72	8.07	3.51	14.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-familial	0.30	30.18	245.59	95.51	539.63
BRCA-familial Exclusive	BRCA_ReactomeCoreGenes_atleast8	0.13	29.32	115.34	48.35	165.80
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-familial Exclusive	0.12	4.04	73.96	31.85	152.35
BRCA-familial Exclusive	BRCA_ReactomeCoreGenes_atleast8 Exclusive	0.08	22.05	73.94	36.46	116.38
BRCA_ReactomeCoreGenes_atleast8 Exclusive	Overlap	0.22	150.52	641.72	204.66	640.95
BRCA-familial Exclusive	Overlap	0.16	79.29	355.38	252.63	487.19
Overlap	Exclusives	0.10	45.00	97.40	46.70	140.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA_ReactomeCoreGenes_atleast8 Exclusive	206	206	
BRCA-familial Exclusive	14	14	
Overlap	9	9