Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-gwas	8.47e-02	5.83e-01	8.52e-09	3.13e-07
BRCA-gwas Exclusive	BRCA_ReactomeCoreGenes_atleast8	1.92e-01	4.96e-02	1.39e-16	1.88e-14
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-gwas Exclusive	7.81e-02	7.60e-01	2.64e-07	1.38e-06
BRCA-gwas Exclusive	BRCA_ReactomeCoreGenes_atleast8 Exclusive	2.29e-01	7.20e-02	5.24e-16	3.26e-13
BRCA_ReactomeCoreGenes_atleast8 Exclusive	Overlap	5.90e-04	3.92e-03	1.88e-09	8.67e-08
BRCA-gwas Exclusive	Overlap	2.02e-03	7.20e-04	3.44e-09	5.90e-09
Overlap	Exclusives	1.98e-10	2.59e-10	4.43e-79	4.52e-35



Evaluating how well BRCA_ReactomeCoreGenes_atleast8 genes are linked to BRCA-gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-gwas	0.63	0.25	1.03	1.98	6.14
BRCA-gwas Exclusive	BRCA_ReactomeCoreGenes_atleast8	0.68	-0.08	2.54	1.93	10.07
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-gwas Exclusive	0.62	-0.02	0.57	1.65	5.50
BRCA-gwas Exclusive	BRCA_ReactomeCoreGenes_atleast8 Exclusive	0.67	0.20	2.00	1.72	8.44
BRCA_ReactomeCoreGenes_atleast8 Exclusive	Overlap	0.98	2.12	2.75	1.92	3.65
BRCA-gwas Exclusive	Overlap	0.99	1.83	1.73	2.76	3.93
Overlap	Exclusives	0.72	4.77	8.46	3.48	17.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-gwas	0.02	-0.72	3.71	3.48	9.19
BRCA-gwas Exclusive	BRCA_ReactomeCoreGenes_atleast8	0.03	1.25	8.83	5.19	16.90
BRCA_ReactomeCoreGenes_atleast8 Exclusive	BRCA-gwas Exclusive	0.02	-1.69	1.11	1.94	8.42
BRCA-gwas Exclusive	BRCA_ReactomeCoreGenes_atleast8 Exclusive	0.02	0.82	4.02	2.54	12.23
BRCA_ReactomeCoreGenes_atleast8 Exclusive	Overlap	0.03	4.62	55.99	13.46	16.41
BRCA-gwas Exclusive	Overlap	0.05	5.88	45.86	48.62	72.53
Overlap	Exclusives	0.06	9.73	29.63	13.93	41.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
BRCA_ReactomeCoreGenes_atleast8 Exclusive	210	210	
BRCA-gwas Exclusive	168	168	
Overlap	5	5