Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_EA Exclusive	Familial	7.98e-01	3.59e-01	6.29e-01	1.29e-05
Familial Exclusive	mu_EA	4.19e-07	4.87e-01	7.97e-10	6.54e-03
mu_EA Exclusive	Familial Exclusive	7.40e-01	3.63e-01	5.68e-01	3.31e-05
Familial Exclusive	mu_EA Exclusive	2.48e-07	4.14e-01	3.46e-09	6.97e-03
mu_EA Exclusive	Overlap	5.74e-01	1.98e-02	6.14e-01	1.39e-01
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	3.77e-03	1.67e-02	1.88e-38	7.65e-06



Evaluating how well mu_EA genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA Exclusive	Familial	0.80	0.32	0.38	0.27	4.58
Familial Exclusive	mu_EA	0.55	0.95	1.30	1.01	2.60
mu_EA Exclusive	Familial Exclusive	0.79	0.43	0.23	0.38	4.85
Familial Exclusive	mu_EA Exclusive	0.55	0.81	0.94	0.86	2.30
mu_EA Exclusive	Overlap	0.95	0.60	4.57	0.43	1.47
Familial Exclusive	Overlap	1.00	1.01	1.39	1.61	1.74
Overlap	Exclusives	0.60	3.04	2.92	1.25	4.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA Exclusive	Familial	0.01	0.66	-0.11	1.20	19.04
Familial Exclusive	mu_EA	0.01	0.93	0.46	1.09	1.21
mu_EA Exclusive	Familial Exclusive	0.01	0.85	-0.16	0.93	16.03
Familial Exclusive	mu_EA Exclusive	0.01	0.57	0.51	0.45	1.41
mu_EA Exclusive	Overlap	0.00	-0.08	12.72	-0.31	0.35
Familial Exclusive	Overlap	0.01	0.44	39.33	30.30	7.24
Overlap	Exclusives	0.02	12.01	12.45	4.79	14.57

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_EA Exclusive	190	184	TEX52;SMIM6;AP000781.2;ATP5MF-PTCD1;CBS;C16orf86
Familial Exclusive	22	22	
Overlap	1	1