Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_spliceAI Exclusive	Familial	1.87e-01	6.01e-01	2.86e-01	3.18e-07
Familial Exclusive	mu_spliceAI	4.36e-07	7.86e-01	1.00e-06	5.47e-01
mu_spliceAI Exclusive	Familial Exclusive	1.32e-01	7.12e-01	1.35e-01	7.93e-08
Familial Exclusive	mu_spliceAI Exclusive	3.58e-07	7.60e-01	1.78e-06	6.67e-01
mu_spliceAI Exclusive	Overlap	9.70e-01	7.33e-01	8.32e-01	6.93e-01
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.75e-03	2.04e-03	8.50e-06	1.75e-03



Evaluating how well mu_spliceAI genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_spliceAI Exclusive	Familial	0.80	0.78	0.84	0.42	4.74
Familial Exclusive	mu_spliceAI	0.52	-1.72	-0.43	-0.64	0.66
mu_spliceAI Exclusive	Familial Exclusive	0.81	0.73	0.93	0.65	5.18
Familial Exclusive	mu_spliceAI Exclusive	0.51	-1.55	-0.50	-0.54	0.37
mu_spliceAI Exclusive	Overlap	0.63	0.05	-0.28	0.19	0.52
Familial Exclusive	Overlap	1.00	1.75	1.51	2.58	1.59
Overlap	Exclusives	0.58	0.23	0.79	0.53	3.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_spliceAI Exclusive	Familial	0.00	-0.36	-2.45	-0.54	2.16
Familial Exclusive	mu_spliceAI	0.01	1.31	1.01	0.32	0.52
mu_spliceAI Exclusive	Familial Exclusive	0.00	-0.36	-2.78	-0.35	2.53
Familial Exclusive	mu_spliceAI Exclusive	0.01	-0.55	-0.18	-0.43	0.02
mu_spliceAI Exclusive	Overlap	0.00	-0.28	-0.53	-0.25	-0.23
Familial Exclusive	Overlap	0.03	98.78	175.35	388.44	200.71
Overlap	Exclusives	0.03	15.87	24.15	11.80	17.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_spliceAI Exclusive	120	118	AC139530.2;AC113554.1
Familial Exclusive	22	22	
Overlap	1	1