Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_EA_spliceAI_AF1 Exclusive	Familial	1.27e-01	1.30e-01	3.45e-02	1.97e-08
Familial Exclusive	mu_EA_spliceAI_AF1	3.97e-05	3.25e-01	6.27e-12	1.24e-03
mu_EA_spliceAI_AF1 Exclusive	Familial Exclusive	1.04e-01	1.84e-01	5.97e-02	3.37e-07
Familial Exclusive	mu_EA_spliceAI_AF1 Exclusive	3.97e-05	3.38e-01	8.48e-13	8.65e-04
mu_EA_spliceAI_AF1 Exclusive	Overlap	7.92e-02	1.98e-02	7.92e-02	9.90e-02
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.56e-04	2.59e-03	3.21e-46	2.04e-07



Evaluating how well mu_EA_spliceAI_AF1 genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA_spliceAI_AF1 Exclusive	Familial	0.87	1.23	2.82	1.02	5.98
Familial Exclusive	mu_EA_spliceAI_AF1	0.59	1.99	2.44	1.85	3.72
mu_EA_spliceAI_AF1 Exclusive	Familial Exclusive	0.86	1.24	2.59	0.99	5.85
Familial Exclusive	mu_EA_spliceAI_AF1 Exclusive	0.58	2.16	2.64	2.42	4.22
mu_EA_spliceAI_AF1 Exclusive	Overlap	0.98	1.18	1.53	1.01	1.49
Familial Exclusive	Overlap	1.00	1.20	1.36	1.96	1.77
Overlap	Exclusives	0.62	3.18	3.50	1.83	7.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_EA_spliceAI_AF1 Exclusive	Familial	0.06	3.22	17.51	8.42	131.41
Familial Exclusive	mu_EA_spliceAI_AF1	0.01	2.31	1.54	2.12	3.47
mu_EA_spliceAI_AF1 Exclusive	Familial Exclusive	0.06	4.58	16.59	10.88	143.48
Familial Exclusive	mu_EA_spliceAI_AF1 Exclusive	0.01	1.33	1.16	3.28	4.02
mu_EA_spliceAI_AF1 Exclusive	Overlap	0.00	1.84	3.54	0.25	0.07
Familial Exclusive	Overlap	0.01	4.24	39.38	51.24	21.34
Overlap	Exclusives	0.02	3.70	14.98	6.02	15.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_EA_spliceAI_AF1 Exclusive	206	199	C16orf86;AP000781.2;TEX52;SMIM6;CBS;PRR36;AC069368.1
Familial Exclusive	22	22	
Overlap	1	1