Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_spliceAI_AF001_3 Exclusive	Familial	9.18e-01	6.57e-01	7.65e-01	4.17e-03
Familial Exclusive	mu_spliceAI_AF001_3	2.33e-02	8.96e-01	1.66e-05	8.40e-01
mu_spliceAI_AF001_3 Exclusive	Familial Exclusive	8.36e-01	5.79e-01	8.30e-01	4.66e-03
Familial Exclusive	mu_spliceAI_AF001_3 Exclusive	2.50e-02	9.31e-01	1.17e-04	9.11e-01
mu_spliceAI_AF001_3 Exclusive	Overlap	8.51e-01	1.98e-02	5.74e-01	4.16e-01
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.58e-04	7.93e-03	6.97e-21	2.31e-03



Evaluating how well mu_spliceAI_AF001_3 genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_spliceAI_AF001_3 Exclusive	Familial	0.71	-0.24	-0.26	-0.47	3.89
Familial Exclusive	mu_spliceAI_AF001_3	0.52	0.99	0.30	0.53	0.48
mu_spliceAI_AF001_3 Exclusive	Familial Exclusive	0.71	-0.31	-0.38	-0.36	3.51
Familial Exclusive	mu_spliceAI_AF001_3 Exclusive	0.51	1.02	0.19	0.20	0.42
mu_spliceAI_AF001_3 Exclusive	Overlap	0.82	-0.08	1.24	-0.43	1.06
Familial Exclusive	Overlap	1.00	1.01	1.29	1.74	2.03
Overlap	Exclusives	0.59	2.13	2.28	1.10	3.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_spliceAI_AF001_3 Exclusive	Familial	0.00	-0.41	-1.26	-0.73	3.45
Familial Exclusive	mu_spliceAI_AF001_3	0.01	0.63	-0.10	0.03	-0.06
mu_spliceAI_AF001_3 Exclusive	Familial Exclusive	0.00	-0.51	-1.49	-0.63	1.75
Familial Exclusive	mu_spliceAI_AF001_3 Exclusive	0.01	0.39	-0.23	-0.23	-0.24
mu_spliceAI_AF001_3 Exclusive	Overlap	0.00	-0.48	1.48	-0.54	-0.01
Familial Exclusive	Overlap	0.01	1.54	37.79	23.18	31.89
Overlap	Exclusives	0.02	19.16	19.07	6.23	18.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_spliceAI_AF001_3 Exclusive	103	99	CBS;C16orf86;AP000781.2;PRR36
Familial Exclusive	22	22	
Overlap	1	1