Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA	somatic	1.32e-01	2.14e-01	2.06e-02	1.31e-12
somatic	EA	2.20e-02	3.97e-01	2.59e-09	4.59e-02



Evaluating how well EA genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA	somatic	0.86	1.02	1.17	0.99	7.36
somatic	EA	0.55	-0.39	1.51	1.15	2.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA	somatic	0.02	0.32	-0.13	1.14	28.06
somatic	EA	0.01	-0.26	1.52	1.10	1.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA	191	185	TEX52;CBS;ATP5MF-PTCD1;AP000781.2;C16orf86;SMIM6
somatic	37	37