Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_spliceAI_CHEK2_excl	familial	1.25e-01	1.15e-01	3.37e-02	8.21e-08
familial	EA_spliceAI_CHEK2_excl	6.19e-05	2.29e-01	8.33e-12	6.87e-04



Evaluating how well EA_spliceAI_CHEK2_excl genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_spliceAI_CHEK2_excl	familial	0.87	1.20	3.00	0.93	6.32
familial	EA_spliceAI_CHEK2_excl	0.58	2.81	2.78	2.30	3.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_spliceAI_CHEK2_excl	familial	0.06	4.26	17.49	13.37	80.87
familial	EA_spliceAI_CHEK2_excl	0.01	1.69	2.16	2.84	2.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_spliceAI_CHEK2_excl	206	199	C16orf86;SMIM6;PRR36;AP000781.2;AC069368.1;CBS;TEX52
familial	23	23