Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_AF_01_195 Exclusive	adgs_25_genes	4.75e-01	5.97e-01	7.74e-01	1.65e-01
adgs_25_genes Exclusive	EAML_AF_01_195	7.97e-03	2.39e-01	4.66e-03	1.26e-01
EAML_AF_01_195 Exclusive	adgs_25_genes Exclusive	5.20e-01	5.97e-01	9.38e-01	1.76e-01
adgs_25_genes Exclusive	EAML_AF_01_195 Exclusive	8.24e-03	3.18e-01	2.57e-03	2.22e-01
EAML_AF_01_195 Exclusive	Overlap	1.06e-01	1.41e-01	3.35e-01	7.92e-01
adgs_25_genes Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	2.72e-01	2.59e-01	1.80e-04	1.75e-02



Evaluating how well EAML_AF_01_195 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_AF_01_195 Exclusive	adgs_25_genes	0.58	-1.14	-1.31	-0.65	1.55
adgs_25_genes Exclusive	EAML_AF_01_195	0.53	0.01	0.63	0.79	1.68
EAML_AF_01_195 Exclusive	adgs_25_genes Exclusive	0.60	-0.82	-0.70	-0.31	1.54
adgs_25_genes Exclusive	EAML_AF_01_195 Exclusive	0.52	-0.13	0.52	0.57	0.95
EAML_AF_01_195 Exclusive	Overlap	0.37	-1.99	-1.95	-1.41	-0.47
adgs_25_genes Exclusive	Overlap	1.00	2.82	3.08	2.88	2.44
Overlap	Exclusives	0.55	0.42	1.68	0.94	2.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_AF_01_195 Exclusive	adgs_25_genes	0.00	-0.81	-1.81	-0.61	0.19
adgs_25_genes Exclusive	EAML_AF_01_195	0.01	1.39	0.43	1.46	1.88
EAML_AF_01_195 Exclusive	adgs_25_genes Exclusive	0.00	-0.63	-1.77	-0.57	0.16
adgs_25_genes Exclusive	EAML_AF_01_195 Exclusive	0.01	-0.64	-0.66	-0.48	-0.01
EAML_AF_01_195 Exclusive	Overlap	0.00	-0.83	-1.02	-0.37	-0.16
adgs_25_genes Exclusive	Overlap	0.11	275.40	877.22	836.52	62.71
Overlap	Exclusives	0.02	9.47	11.53	10.47	11.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_AF_01_195 Exclusive	193	192	AC131097.2
adgs_25_genes Exclusive	23	22	HLA -DRB1
Overlap	2	2