Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice_canon Exclusive	Familial	7.62e-02	1.74e-01	2.73e-02	6.70e-09
Familial Exclusive	splice_canon	3.42e-05	2.74e-01	2.89e-12	4.82e-03
splice_canon Exclusive	Familial Exclusive	6.11e-02	1.51e-01	3.62e-02	1.42e-08
Familial Exclusive	splice_canon Exclusive	4.78e-05	2.64e-01	7.18e-13	3.97e-03
splice_canon Exclusive	Overlap	3.37e-01	1.98e-02	2.18e-01	7.92e-02
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.72e-03	1.11e-02	8.58e-38	9.03e-06



Evaluating how well splice_canon genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_canon Exclusive	Familial	0.86	1.24	2.84	1.01	5.94
Familial Exclusive	splice_canon	0.57	1.62	2.12	1.79	3.37
splice_canon Exclusive	Familial Exclusive	0.86	1.24	2.78	0.98	5.65
Familial Exclusive	splice_canon Exclusive	0.57	1.70	2.40	1.96	3.69
splice_canon Exclusive	Overlap	0.96	0.79	1.99	0.80	1.57
Familial Exclusive	Overlap	1.00	1.00	1.34	1.55	2.04
Overlap	Exclusives	0.60	2.01	3.07	1.28	5.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_canon Exclusive	Familial	0.01	0.60	1.76	2.17	19.54
Familial Exclusive	splice_canon	0.01	1.36	2.76	2.49	2.41
splice_canon Exclusive	Familial Exclusive	0.01	1.59	1.67	2.21	33.59
Familial Exclusive	splice_canon Exclusive	0.01	1.86	2.82	1.79	3.44
splice_canon Exclusive	Overlap	0.00	0.48	3.01	0.22	2.77
Familial Exclusive	Overlap	0.01	1.15	38.71	26.09	24.21
Overlap	Exclusives	0.02	2.81	12.50	3.95	12.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice_canon Exclusive	194	189	TEX52;C16orf86;SMIM6;CBS;AP000781.2
Familial Exclusive	22	22	
Overlap	1	1