Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice_canon Exclusive	somatic	7.53e-02	4.06e-01	6.62e-02	8.03e-11
somatic Exclusive	splice_canon	1.23e-02	3.65e-01	9.31e-10	3.69e-02
splice_canon Exclusive	somatic Exclusive	1.45e-01	5.06e-01	4.93e-02	4.20e-10
somatic Exclusive	splice_canon Exclusive	1.49e-02	5.42e-01	4.50e-09	8.24e-02
splice_canon Exclusive	Overlap	6.73e-01	8.12e-01	4.75e-01	2.18e-01
somatic Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	8.65e-02	4.55e-02	1.08e-34	1.68e-03



Evaluating how well splice_canon genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_canon Exclusive	somatic	0.85	1.06	0.84	0.54	7.46
somatic Exclusive	splice_canon	0.55	-0.11	1.43	0.97	2.79
splice_canon Exclusive	somatic Exclusive	0.85	0.95	0.68	0.67	7.95
somatic Exclusive	splice_canon Exclusive	0.55	-0.20	1.46	1.12	2.50
splice_canon Exclusive	Overlap	0.94	0.60	0.36	0.64	1.48
somatic Exclusive	Overlap	0.99	0.94	1.56	1.41	2.07
Overlap	Exclusives	0.57	-0.96	-0.21	0.27	3.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_canon Exclusive	somatic	0.02	0.12	0.05	0.72	24.38
somatic Exclusive	splice_canon	0.01	0.25	1.81	1.42	2.42
splice_canon Exclusive	somatic Exclusive	0.02	0.09	-0.04	0.88	39.60
somatic Exclusive	splice_canon Exclusive	0.01	-0.11	1.56	0.95	1.36
splice_canon Exclusive	Overlap	0.00	-0.26	-0.50	-0.20	-0.00
somatic Exclusive	Overlap	0.00	2.30	26.07	11.63	16.37
Overlap	Exclusives	0.02	0.32	2.62	1.13	5.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice_canon Exclusive	194	189	C16orf86;CBS;SMIM6;AP000781.2;TEX52
somatic Exclusive	36	36	
Overlap	1	1