Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice_canon Exclusive	Familial	6.18e-02	1.89e-01	5.91e-02	3.97e-09
Familial Exclusive	splice_canon	6.06e-05	2.64e-01	6.58e-12	1.58e-03
splice_canon Exclusive	Familial Exclusive	4.45e-02	1.83e-01	9.67e-03	5.29e-08
Familial Exclusive	splice_canon Exclusive	3.18e-05	3.44e-01	2.44e-12	3.02e-03
splice_canon Exclusive	Overlap	3.37e-01	1.98e-02	1.98e-01	1.19e-01
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.45e-03	9.59e-03	1.06e-52	8.43e-06



Evaluating how well splice_canon genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_canon Exclusive	Familial	0.86	1.37	2.49	0.86	5.77
Familial Exclusive	splice_canon	0.57	1.93	2.15	1.68	3.60
splice_canon Exclusive	Familial Exclusive	0.86	1.49	2.31	1.25	5.86
Familial Exclusive	splice_canon Exclusive	0.57	1.49	1.99	1.60	3.21
splice_canon Exclusive	Overlap	0.96	0.69	2.17	0.80	1.56
Familial Exclusive	Overlap	1.00	1.03	1.30	1.89	1.68
Overlap	Exclusives	0.60	2.46	3.37	1.58	4.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_canon Exclusive	Familial	0.01	1.68	1.91	1.89	18.72
Familial Exclusive	splice_canon	0.01	1.95	3.11	2.39	3.37
splice_canon Exclusive	Familial Exclusive	0.01	1.24	1.69	3.19	33.53
Familial Exclusive	splice_canon Exclusive	0.01	1.53	2.40	1.69	2.62
splice_canon Exclusive	Overlap	0.00	0.04	3.35	0.20	0.94
Familial Exclusive	Overlap	0.01	0.61	39.43	24.81	22.84
Overlap	Exclusives	0.02	3.40	14.36	6.66	9.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice_canon Exclusive	194	189	TEX52;C16orf86;AP000781.2;CBS;SMIM6
Familial Exclusive	22	22	
Overlap	1	1