Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA_all_splice Exclusive	familial	1.80e-01	2.95e-01	3.58e-03	9.63e-11
familial Exclusive	EA_all_splice	5.48e-04	2.03e-01	3.21e-10	4.29e-03
EA_all_splice Exclusive	familial Exclusive	3.03e-01	2.23e-01	4.30e-03	1.45e-09
familial Exclusive	EA_all_splice Exclusive	3.60e-04	2.60e-01	1.94e-09	1.23e-02
EA_all_splice Exclusive	Overlap	2.73e-01	9.85e-05	2.49e-02	8.97e-03
familial Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	2.35e-03	6.67e-03	8.01e-32	2.11e-05



Evaluating how well EA_all_splice genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_all_splice Exclusive	familial	0.89	1.14	2.61	1.49	6.80
familial Exclusive	EA_all_splice	0.58	1.40	2.40	2.02	3.74
EA_all_splice Exclusive	familial Exclusive	0.88	0.98	2.83	1.45	6.24
familial Exclusive	EA_all_splice Exclusive	0.57	1.39	2.30	1.68	3.51
EA_all_splice Exclusive	Overlap	0.95	0.53	1.89	1.19	2.42
familial Exclusive	Overlap	1.00	1.75	2.57	2.11	2.65
Overlap	Exclusives	0.62	2.42	3.84	1.69	6.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA_all_splice Exclusive	familial	0.01	-0.08	1.26	1.19	19.50
familial Exclusive	EA_all_splice	0.01	1.25	1.11	2.80	5.94
EA_all_splice Exclusive	familial Exclusive	0.01	-0.18	1.07	1.44	20.39
familial Exclusive	EA_all_splice Exclusive	0.01	0.56	0.78	1.92	3.67
EA_all_splice Exclusive	Overlap	0.00	-0.20	3.70	0.57	3.42
familial Exclusive	Overlap	0.02	4.25	140.33	45.10	43.15
Overlap	Exclusives	0.03	5.04	17.87	8.13	14.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA_all_splice Exclusive	180	174	CBS;SMIM6;BORCS8-MEF2B;C16orf86;AP000781.2;TEX52
familial Exclusive	21	21	
Overlap	2	2