Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI 0001 Exclusive	Familial	4.44e-01	7.51e-01	5.12e-01	1.43e-06
Familial Exclusive	EA spliceAI 0001	3.13e-09	6.44e-01	7.60e-23	1.97e-01
EA spliceAI 0001 Exclusive	Familial Exclusive	5.12e-01	7.15e-01	8.21e-01	3.79e-05
Familial Exclusive	EA spliceAI 0001 Exclusive	9.27e-09	6.24e-01	1.77e-24	2.07e-01
EA spliceAI 0001 Exclusive	Overlap	3.01e-01	1.93e-01	4.07e-01	4.13e-02
Familial Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	1.35e-03	4.20e-02	2.23e-32	2.35e-03



Evaluating how well EA spliceAI 0001 genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI 0001 Exclusive	Familial	0.80	0.33	0.16	-0.19	4.73
Familial Exclusive	EA spliceAI 0001	0.52	1.04	0.73	0.53	1.20
EA spliceAI 0001 Exclusive	Familial Exclusive	0.79	0.43	-0.14	-0.26	4.47
Familial Exclusive	EA spliceAI 0001 Exclusive	0.51	1.23	0.63	0.33	0.94
EA spliceAI 0001 Exclusive	Overlap	0.83	0.52	0.29	0.27	2.64
Familial Exclusive	Overlap	1.00	1.73	3.70	2.52	3.74
Overlap	Exclusives	0.56	4.18	2.90	2.40	4.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI 0001 Exclusive	Familial	0.02	0.56	1.78	1.34	54.63
Familial Exclusive	EA spliceAI 0001	0.02	7.11	5.49	4.30	5.16
EA spliceAI 0001 Exclusive	Familial Exclusive	0.02	0.48	1.61	1.88	31.18
Familial Exclusive	EA spliceAI 0001 Exclusive	0.02	1.49	0.76	0.07	0.39
EA spliceAI 0001 Exclusive	Overlap	0.00	0.88	2.86	0.61	14.59
Familial Exclusive	Overlap	0.28	105.09	1365.87	580.24	1187.23
Overlap	Exclusives	0.03	13.15	9.70	6.98	9.81

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI 0001 Exclusive	328	319	SMIM6;RNASE4;AC069368.1;PRR36;AP000781.2;TEX52;CBS;C16orf86;AC099811.2
Familial Exclusive	19	19	
Overlap	4	4