Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SpliceAI 0001 Exclusive	Somatic	1.89e-01	6.48e-01	6.14e-01	2.85e-11
Somatic Exclusive	SpliceAI 0001	6.61e-04	4.68e-01	6.70e-15	4.86e-01
SpliceAI 0001 Exclusive	Somatic Exclusive	2.40e-01	6.41e-01	4.09e-01	3.30e-09
Somatic Exclusive	SpliceAI 0001 Exclusive	5.88e-04	7.28e-01	6.07e-15	6.71e-01
SpliceAI 0001 Exclusive	Overlap	7.70e-01	5.20e-01	9.37e-01	5.58e-03
Somatic Exclusive	Overlap	1.83e-09	1.99e-03	1.83e-09	9.14e-09
Overlap	Exclusives	2.15e-03	5.25e-02	5.51e-54	5.41e-03



Evaluating how well SpliceAI 0001 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI 0001 Exclusive	Somatic	0.84	0.36	-0.86	-0.70	6.19
Somatic Exclusive	SpliceAI 0001	0.52	-1.00	0.93	0.29	1.26
SpliceAI 0001 Exclusive	Somatic Exclusive	0.83	0.12	-1.05	-0.44	6.82
Somatic Exclusive	SpliceAI 0001 Exclusive	0.51	-0.82	0.45	0.30	0.78
SpliceAI 0001 Exclusive	Overlap	0.90	0.42	0.11	-0.14	2.98
Somatic Exclusive	Overlap	0.99	2.00	2.98	2.46	3.46
Overlap	Exclusives	0.56	1.36	2.37	1.54	3.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SpliceAI 0001 Exclusive	Somatic	0.03	0.27	-0.44	0.25	63.96
Somatic Exclusive	SpliceAI 0001	0.02	-0.44	1.26	0.53	1.31
SpliceAI 0001 Exclusive	Somatic Exclusive	0.03	0.15	-1.05	0.53	6.14
Somatic Exclusive	SpliceAI 0001 Exclusive	0.02	-1.10	0.41	-0.21	-0.02
SpliceAI 0001 Exclusive	Overlap	0.00	0.58	2.30	-0.11	2.44
Somatic Exclusive	Overlap	0.01	2.36	10.15	45.62	56.56
Overlap	Exclusives	0.02	3.27	3.60	2.86	4.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SpliceAI 0001 Exclusive	328	319	AP000781.2;TEX52;RNASE4;SMIM6;C16orf86;PRR36;AC069368.1;AC099811.2;CBS
Somatic Exclusive	33	33	
Overlap	4	4