Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI 	somatic	6.29e-02	1.26e-03	6.45e-02	5.04e-05
somatic	spliceAI 	6.78e-02	5.90e-01	1.48e-03	2.71e-01



Evaluating how well spliceAI  genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI 	somatic	0.69	-1.17	-4.26	-1.54	4.01
somatic	spliceAI 	0.51	-2.02	-0.73	-0.56	0.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI 	somatic	0.00	-0.84	-2.60	-0.91	2.32
somatic	spliceAI 	0.00	-1.45	-1.03	-0.83	-0.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI 	53	52	AC139530.2
somatic	37	37