Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
mu_AF_01_pd_157 Exclusive	gp2union	1.01e-01	6.29e-02	8.49e-02	1.69e-04
gp2union Exclusive	mu_AF_01_pd_157	3.02e-01	3.89e-01	8.46e-14	4.74e-01
mu_AF_01_pd_157 Exclusive	gp2union Exclusive	4.58e-02	4.51e-02	6.53e-02	2.39e-04
gp2union Exclusive	mu_AF_01_pd_157 Exclusive	4.56e-01	4.58e-01	2.56e-13	5.22e-01
mu_AF_01_pd_157 Exclusive	Overlap	3.56e-01	8.32e-01	5.54e-01	5.35e-01
gp2union Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.02e-03	6.24e-02	1.88e-08	1.78e-02



Evaluating how well mu_AF_01_pd_157 genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_AF_01_pd_157 Exclusive	gp2union	0.83	2.82	2.93	2.16	5.50
gp2union Exclusive	mu_AF_01_pd_157	0.54	0.79	1.10	1.19	1.66
mu_AF_01_pd_157 Exclusive	gp2union Exclusive	0.83	2.70	2.83	2.41	4.22
gp2union Exclusive	mu_AF_01_pd_157 Exclusive	0.53	0.55	1.32	1.07	1.82
mu_AF_01_pd_157 Exclusive	Overlap	0.74	1.24	0.43	0.71	0.94
gp2union Exclusive	Overlap	1.00	3.69	1.52	2.01	1.68
Overlap	Exclusives	0.55	1.13	1.55	1.14	2.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
mu_AF_01_pd_157 Exclusive	gp2union	0.00	2.51	2.12	1.73	7.02
gp2union Exclusive	mu_AF_01_pd_157	0.01	1.68	4.45	3.56	3.32
mu_AF_01_pd_157 Exclusive	gp2union Exclusive	0.00	3.48	1.13	2.60	6.30
gp2union Exclusive	mu_AF_01_pd_157 Exclusive	0.01	1.80	4.07	2.20	3.81
mu_AF_01_pd_157 Exclusive	Overlap	0.00	0.41	-0.38	-0.10	-0.15
gp2union Exclusive	Overlap	0.01	67.81	18.22	16.53	19.56
Overlap	Exclusives	0.01	1.78	4.16	1.75	2.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
mu_AF_01_pd_157 Exclusive	156	155	AP000781.2
gp2union Exclusive	15	14	GBNMP
Overlap	1	1