Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eaml_pd_af01	gp2union	1.73e-03	1.16e-03	9.50e-04	2.56e-07
gp2union	eaml_pd_af01	2.65e-01	1.86e-01	9.66e-15	1.33e-01



Evaluating how well eaml_pd_af01 genes are linked to gp2union genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml_pd_af01	gp2union	0.85	2.86	4.17	3.10	5.07
gp2union	eaml_pd_af01	0.54	2.34	2.01	1.95	1.86

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eaml_pd_af01	gp2union	0.00	2.62	1.18	2.68	9.56
gp2union	eaml_pd_af01	0.01	4.90	3.90	3.28	3.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eaml_pd_af01	163	161	NT5C1B-RDH14;RNASE4
gp2union	16	15	GBNMP