Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA 001	Familial	9.18e-01	9.25e-01	7.38e-01	3.07e-05
Familial	EA 001	3.95e-09	8.40e-01	2.13e-08	9.94e-02



Evaluating how well EA 001 genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA 001	Familial	0.79	0.28	0.05	0.20	5.33
Familial	EA 001	0.54	0.01	0.12	0.02	1.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA 001	Familial	0.01	0.93	0.65	1.28	23.70
Familial	EA 001	0.01	0.62	0.11	0.20	1.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA 001	198	194	ATP5MF-PTCD1;CBS;C16orf86;AP000781.2
Familial	23	23