Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA 001 Exclusive	Somatic	8.77e-01	5.59e-01	7.30e-01	1.83e-08
Somatic Exclusive	EA 001	7.27e-05	9.97e-01	1.10e-07	2.73e-01
EA 001 Exclusive	Somatic Exclusive	6.75e-01	4.92e-01	3.27e-01	1.13e-08
Somatic Exclusive	EA 001 Exclusive	5.18e-05	9.96e-01	4.01e-07	3.81e-01
EA 001 Exclusive	Overlap	5.37e-01	5.17e-01	6.10e-01	6.61e-01
Somatic Exclusive	Overlap	9.85e-05	4.89e-02	9.85e-05	2.96e-04
Overlap	Exclusives	5.33e-02	2.04e-02	1.35e-39	1.12e-04



Evaluating how well EA 001 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA 001 Exclusive	Somatic	0.81	-0.12	-1.12	-0.66	6.59
Somatic Exclusive	EA 001	0.53	-2.46	0.13	-0.18	1.37
EA 001 Exclusive	Somatic Exclusive	0.82	0.09	-0.66	-0.14	7.39
Somatic Exclusive	EA 001 Exclusive	0.52	-2.18	-0.15	-0.51	1.09
EA 001 Exclusive	Overlap	0.71	-1.64	-2.48	-1.95	0.80
Somatic Exclusive	Overlap	0.99	1.77	1.70	2.18	2.25
Overlap	Exclusives	0.59	-0.52	0.71	0.53	4.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA 001 Exclusive	Somatic	0.01	-0.21	-1.03	0.06	25.02
Somatic Exclusive	EA 001	0.01	-0.89	0.83	0.47	0.73
EA 001 Exclusive	Somatic Exclusive	0.02	-0.17	-1.14	0.50	16.23
Somatic Exclusive	EA 001 Exclusive	0.01	-1.05	0.16	-0.16	0.58
EA 001 Exclusive	Overlap	0.00	-0.72	-0.95	-0.58	-0.10
Somatic Exclusive	Overlap	0.01	1.68	5.56	35.92	31.63
Overlap	Exclusives	0.02	0.63	3.06	1.05	6.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA 001 Exclusive	196	192	ATP5MF-PTCD1;CBS;C16orf86;AP000781.2
Somatic Exclusive	35	35	
Overlap	2	2