Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA splice_region 001 Exclusive	Familial	8.38e-01	4.99e-01	2.48e-01	3.81e-07
Familial Exclusive	EA splice_region 001	1.26e-06	3.74e-01	6.97e-08	2.79e-01
EA splice_region 001 Exclusive	Familial Exclusive	9.00e-01	4.50e-01	3.52e-01	1.28e-06
Familial Exclusive	EA splice_region 001 Exclusive	1.36e-06	3.70e-01	1.30e-07	2.76e-01
EA splice_region 001 Exclusive	Overlap	6.34e-01	1.98e-02	6.53e-01	1.98e-01
Familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.26e-03	3.16e-02	3.20e-32	1.01e-03



Evaluating how well EA splice_region 001 genes are linked to Familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA splice_region 001 Exclusive	Familial	0.82	0.11	0.24	0.53	5.25
Familial Exclusive	EA splice_region 001	0.53	-0.77	-1.09	-0.05	1.41
EA splice_region 001 Exclusive	Familial Exclusive	0.82	0.22	0.28	0.41	4.96
Familial Exclusive	EA splice_region 001 Exclusive	0.53	-0.95	-1.37	-0.19	1.41
EA splice_region 001 Exclusive	Overlap	0.92	-0.69	2.09	0.18	1.49
Familial Exclusive	Overlap	1.00	0.95	1.43	1.97	1.72
Overlap	Exclusives	0.58	0.97	0.42	0.62	3.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA splice_region 001 Exclusive	Familial	0.00	-1.09	-1.64	-0.42	0.50
Familial Exclusive	EA splice_region 001	0.01	-0.92	-0.64	0.39	1.17
EA splice_region 001 Exclusive	Familial Exclusive	0.00	-0.77	-1.89	-0.56	2.45
Familial Exclusive	EA splice_region 001 Exclusive	0.01	-1.33	-0.95	0.09	0.75
EA splice_region 001 Exclusive	Overlap	0.00	-0.60	2.47	-0.37	0.44
Familial Exclusive	Overlap	0.01	0.77	37.29	42.67	21.90
Overlap	Exclusives	0.02	2.67	7.83	4.63	8.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA splice_region 001 Exclusive	189	184	CBS;C16orf86;AP000781.2;ATP5MF-PTCD1;BORCS8-MEF2B
Familial Exclusive	22	22	
Overlap	1	1