Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA splice_region 0001	Somatic	2.68e-01	1.33e-01	2.85e-02	3.08e-15
Somatic	EA splice_region 0001	2.20e-04	9.70e-01	9.72e-10	3.46e-01



Evaluating how well EA splice_region 0001 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA splice_region 0001	Somatic	0.87	0.68	0.94	0.87	6.95
Somatic	EA splice_region 0001	0.52	-2.05	0.08	0.25	1.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA splice_region 0001	Somatic	0.01	-0.90	-1.65	-0.09	24.94
Somatic	EA splice_region 0001	0.01	-1.68	0.46	0.69	1.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA splice_region 0001	234	225	AP000781.2;CBS;RNASE4;ATP5MF-PTCD1;BORCS8-MEF2B;SMIM6;HDGFL2;C16orf86;AC099811.2
Somatic	37	37