Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice region Exclusive	familial	5.05e-01	2.33e-01	6.25e-01	7.01e-06
familial Exclusive	splice region	8.17e-07	8.25e-01	2.74e-10	1.34e-01
splice region Exclusive	familial Exclusive	1.85e-01	1.29e-01	4.56e-01	2.86e-06
familial Exclusive	splice region Exclusive	7.71e-07	7.21e-01	7.44e-10	2.62e-01
splice region Exclusive	Overlap	5.74e-01	5.55e-01	7.08e-01	6.77e-01
familial Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	7.31e-03	3.24e-02	4.86e-14	2.50e-05



Evaluating how well splice region genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice region Exclusive	familial	0.77	-0.53	-1.55	-0.09	4.50
familial Exclusive	splice region	0.54	-0.54	-0.21	0.73	1.93
splice region Exclusive	familial Exclusive	0.79	-0.53	-1.19	0.09	4.69
familial Exclusive	splice region Exclusive	0.53	-0.66	-0.35	0.42	1.58
splice region Exclusive	Overlap	0.56	-1.28	-1.26	-0.91	0.26
familial Exclusive	Overlap	1.00	1.44	2.46	2.13	2.27
Overlap	Exclusives	0.58	2.32	1.41	1.27	4.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice region Exclusive	familial	0.01	-0.40	-2.20	0.58	1.46
familial Exclusive	splice region	0.02	3.81	6.78	7.44	7.62
splice region Exclusive	familial Exclusive	0.01	-0.57	-2.08	0.43	1.46
familial Exclusive	splice region Exclusive	0.01	-1.90	-0.72	0.02	0.63
splice region Exclusive	Overlap	0.00	-0.29	1.51	-0.04	0.29
familial Exclusive	Overlap	0.51	137.83	2216.63	1819.76	1940.14
Overlap	Exclusives	0.02	16.46	13.56	9.16	13.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice region Exclusive	194	193	BORCS8-MEF2B
familial Exclusive	21	21	
Overlap	2	2