Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI splice_region 0001 Exclusive	familial	7.78e-01	3.15e-01	2.83e-01	7.26e-07
familial Exclusive	EA spliceAI splice_region 0001	5.02e-09	3.68e-01	1.57e-13	6.61e-01
EA spliceAI splice_region 0001 Exclusive	familial Exclusive	9.64e-01	8.89e-01	7.66e-01	1.15e-05
familial Exclusive	EA spliceAI splice_region 0001 Exclusive	2.52e-09	4.08e-01	9.15e-14	6.18e-01
EA spliceAI splice_region 0001 Exclusive	Overlap	3.98e-01	7.71e-02	2.82e-01	4.00e-02
familial Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.17e-04	6.21e-02	4.72e-18	1.22e-04



Evaluating how well EA spliceAI splice_region 0001 genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI splice_region 0001 Exclusive	familial	0.81	0.12	0.66	0.29	6.14
familial Exclusive	EA spliceAI splice_region 0001	0.51	-1.00	-1.00	-0.49	0.67
EA spliceAI splice_region 0001 Exclusive	familial Exclusive	0.80	-0.10	-0.27	0.04	4.93
familial Exclusive	EA spliceAI splice_region 0001 Exclusive	0.51	-0.99	-1.07	-0.70	0.46
EA spliceAI splice_region 0001 Exclusive	Overlap	0.90	1.05	2.04	1.38	2.39
familial Exclusive	Overlap	1.00	1.50	3.19	2.15	3.19
Overlap	Exclusives	0.57	3.02	2.00	1.44	4.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI splice_region 0001 Exclusive	familial	0.01	-0.52	-1.20	-0.02	19.64
familial Exclusive	EA spliceAI splice_region 0001	0.02	7.50	6.96	5.77	5.82
EA spliceAI splice_region 0001 Exclusive	familial Exclusive	0.01	-0.54	-1.83	-0.30	8.21
familial Exclusive	EA spliceAI splice_region 0001 Exclusive	0.01	-0.38	-0.52	-0.32	0.18
EA spliceAI splice_region 0001 Exclusive	Overlap	0.00	1.19	8.88	1.34	0.65
familial Exclusive	Overlap	0.36	111.82	2156.80	316.91	568.13
Overlap	Exclusives	0.03	18.23	14.96	8.47	14.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI splice_region 0001 Exclusive	260	252	AP000781.2;BORCS8-MEF2B;AC099811.2;ATP5MF-PTCD1;RNASE4;CBS;C16orf86;HDGFL2
familial Exclusive	20	20	
Overlap	3	3