Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI_03 AF_1 Exclusive	Somatic	8.69e-02	9.45e-02	2.79e-02	9.56e-13
Somatic Exclusive	EA spliceAI_03 AF_1	7.27e-03	8.43e-01	1.23e-08	1.13e-01
EA spliceAI_03 AF_1 Exclusive	Somatic Exclusive	1.89e-01	1.33e-01	7.68e-02	5.67e-13
Somatic Exclusive	EA spliceAI_03 AF_1 Exclusive	3.75e-03	8.74e-01	1.52e-08	2.02e-01
EA spliceAI_03 AF_1 Exclusive	Overlap	2.97e-01	5.94e-01	3.96e-01	1.39e-01
Somatic Exclusive	Overlap	1.98e-02	5.15e-01	1.98e-02	5.94e-02
Overlap	Exclusives	9.05e-01	5.16e-02	8.75e-35	1.83e-07



Evaluating how well EA spliceAI_03 AF_1 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_03 AF_1 Exclusive	Somatic	0.83	0.24	0.12	0.16	7.42
Somatic Exclusive	EA spliceAI_03 AF_1	0.54	0.04	0.88	0.60	2.01
EA spliceAI_03 AF_1 Exclusive	Somatic Exclusive	0.83	0.13	-0.16	-0.14	7.08
Somatic Exclusive	EA spliceAI_03 AF_1 Exclusive	0.54	-0.16	0.72	0.47	2.06
EA spliceAI_03 AF_1 Exclusive	Overlap	0.92	0.89	1.01	0.79	1.40
Somatic Exclusive	Overlap	0.99	1.55	0.76	1.72	1.66
Overlap	Exclusives	0.61	0.85	3.33	1.55	5.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_03 AF_1 Exclusive	Somatic	0.02	-0.12	2.16	0.52	32.78
Somatic Exclusive	EA spliceAI_03 AF_1	0.01	0.16	0.88	0.83	1.42
EA spliceAI_03 AF_1 Exclusive	Somatic Exclusive	0.02	-0.32	2.08	0.46	35.11
Somatic Exclusive	EA spliceAI_03 AF_1 Exclusive	0.01	-0.03	0.67	0.43	0.91
EA spliceAI_03 AF_1 Exclusive	Overlap	0.00	0.20	-0.30	0.09	-0.05
Somatic Exclusive	Overlap	0.00	5.56	0.66	17.44	5.55
Overlap	Exclusives	0.02	0.01	5.45	2.16	6.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI_03 AF_1 Exclusive	204	197	AL035460.1;CBS;SMIM6;AC005726.1;C16orf86;AP000781.2;TEX52
Somatic Exclusive	36	36	
Overlap	1	1