Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI_03 AF_1	Somatic	4.96e-01	1.61e-01	8.69e-01	2.33e-05
Somatic	spliceAI_03 AF_1	2.08e-02	6.67e-01	6.61e-05	2.41e-01



Evaluating how well spliceAI_03 AF_1 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_03 AF_1	Somatic	0.75	-1.18	-2.60	-0.98	5.86
Somatic	spliceAI_03 AF_1	0.52	0.34	-0.39	-0.42	1.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_03 AF_1	Somatic	0.01	-0.94	-0.24	-0.51	8.62
Somatic	spliceAI_03 AF_1	0.01	-0.53	-0.71	-0.75	-0.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI_03 AF_1	99	97	C20orf141;AC139530.2
Somatic	37	37