Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI_04 Exclusive	Somatic	3.25e-01	6.36e-01	1.95e-01	3.90e-11
Somatic Exclusive	EA spliceAI_04	1.80e-03	4.08e-01	1.00e-09	4.54e-02
EA spliceAI_04 Exclusive	Somatic Exclusive	5.07e-01	7.58e-01	3.52e-01	1.66e-10
Somatic Exclusive	EA spliceAI_04 Exclusive	1.60e-03	3.17e-01	3.17e-10	7.04e-02
EA spliceAI_04 Exclusive	Overlap	3.17e-01	6.73e-01	4.55e-01	1.58e-01
Somatic Exclusive	Overlap	1.98e-02	5.94e-01	1.98e-02	3.96e-02
Overlap	Exclusives	4.15e-01	3.98e-02	5.13e-39	2.45e-07



Evaluating how well EA spliceAI_04 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_04 Exclusive	Somatic	0.84	0.58	-0.29	0.38	7.76
Somatic Exclusive	EA spliceAI_04	0.55	-0.42	1.29	0.95	2.48
EA spliceAI_04 Exclusive	Somatic Exclusive	0.84	0.58	-0.30	0.23	6.61
Somatic Exclusive	EA spliceAI_04 Exclusive	0.55	-0.44	1.28	1.15	2.09
EA spliceAI_04 Exclusive	Overlap	0.91	0.91	0.82	0.56	1.40
Somatic Exclusive	Overlap	0.99	1.46	0.63	1.44	1.63
Overlap	Exclusives	0.62	1.14	4.24	1.82	7.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_04 Exclusive	Somatic	0.02	-0.15	-0.81	0.52	25.58
Somatic Exclusive	EA spliceAI_04	0.01	-0.33	1.18	0.53	1.88
EA spliceAI_04 Exclusive	Somatic Exclusive	0.02	-0.15	-0.76	0.38	23.28
Somatic Exclusive	EA spliceAI_04 Exclusive	0.01	-0.38	1.01	0.60	0.88
EA spliceAI_04 Exclusive	Overlap	0.00	0.26	-0.21	-0.04	0.64
Somatic Exclusive	Overlap	0.00	2.69	0.52	10.72	0.05
Overlap	Exclusives	0.02	0.28	5.80	1.99	8.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI_04 Exclusive	201	196	C16orf86;CBS;AP000781.2;SMIM6;TEX52
Somatic Exclusive	36	36	
Overlap	1	1