Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI_03 AF_1	familial	8.09e-03	7.79e-02	1.64e-03	1.56e-11
familial	spliceAI_03 AF_1	7.57e-03	6.91e-01	5.85e-05	1.76e-01



Evaluating how well spliceAI_03 AF_1 genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_03 AF_1	familial	0.88	1.47	3.21	1.48	5.83
familial	spliceAI_03 AF_1	0.56	1.75	1.18	0.97	2.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_03 AF_1	familial	0.01	0.25	2.77	0.57	3.17
familial	spliceAI_03 AF_1	0.01	1.87	1.75	1.27	1.69

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI_03 AF_1	99	97	AC139530.2;C20orf141
familial	23	23