Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI_03 AF_1	somatic	6.03e-01	1.40e-01	9.53e-01	1.06e-05
somatic	spliceAI_03 AF_1	1.06e-02	5.76e-01	1.43e-04	2.91e-01



Evaluating how well spliceAI_03 AF_1 genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_03 AF_1	somatic	0.75	-1.01	-2.33	-0.74	5.44
somatic	spliceAI_03 AF_1	0.52	0.17	-0.51	-0.43	0.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_03 AF_1	somatic	0.01	-0.90	-0.17	-0.44	7.68
somatic	spliceAI_03 AF_1	0.01	-0.68	-0.93	-0.68	-0.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI_03 AF_1	99	97	C20orf141;AC139530.2
somatic	37	37