Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI_03 AF_1 Exclusive	Somatic	8.69e-02	1.33e-01	2.58e-02	1.76e-13
Somatic Exclusive	EA spliceAI_03 AF_1	1.06e-03	9.03e-01	2.33e-08	1.81e-01
EA spliceAI_03 AF_1 Exclusive	Somatic Exclusive	2.44e-01	1.89e-01	5.75e-02	1.21e-12
Somatic Exclusive	EA spliceAI_03 AF_1 Exclusive	6.90e-04	8.83e-01	7.32e-09	1.67e-01
EA spliceAI_03 AF_1 Exclusive	Overlap	4.16e-01	7.92e-01	5.15e-01	1.78e-01
Somatic Exclusive	Overlap	1.98e-02	7.92e-01	1.98e-02	3.96e-02
Overlap	Exclusives	7.40e-01	6.53e-02	2.66e-34	3.74e-07



Evaluating how well EA spliceAI_03 AF_1 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_03 AF_1 Exclusive	Somatic	0.83	0.37	-0.20	0.14	8.02
Somatic Exclusive	EA spliceAI_03 AF_1	0.54	-0.13	0.78	0.52	2.08
EA spliceAI_03 AF_1 Exclusive	Somatic Exclusive	0.83	0.06	-0.30	0.02	7.00
Somatic Exclusive	EA spliceAI_03 AF_1 Exclusive	0.54	-0.28	0.91	0.66	2.14
EA spliceAI_03 AF_1 Exclusive	Overlap	0.92	0.88	0.75	0.64	1.43
Somatic Exclusive	Overlap	0.99	1.39	0.67	1.73	1.55
Overlap	Exclusives	0.61	0.97	3.01	1.84	6.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_03 AF_1 Exclusive	Somatic	0.02	-0.20	0.70	0.54	35.67
Somatic Exclusive	EA spliceAI_03 AF_1	0.01	0.18	0.93	0.61	0.83
EA spliceAI_03 AF_1 Exclusive	Somatic Exclusive	0.02	-0.32	0.88	0.38	15.73
Somatic Exclusive	EA spliceAI_03 AF_1 Exclusive	0.01	0.07	0.93	0.48	1.40
EA spliceAI_03 AF_1 Exclusive	Overlap	0.00	0.41	-0.49	-0.10	-0.07
Somatic Exclusive	Overlap	0.00	6.45	0.38	23.00	3.00
Overlap	Exclusives	0.02	0.18	4.63	1.98	7.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI_03 AF_1 Exclusive	204	197	TEX52;AP000781.2;CBS;AC005726.1;C16orf86;SMIM6;AL035460.1
Somatic Exclusive	36	36	
Overlap	1	1