Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI_04 AF_1 Exclusive	Somatic	3.48e-01	4.87e-01	2.45e-01	2.08e-11
Somatic Exclusive	EA spliceAI_04 AF_1	8.87e-03	3.49e-01	1.20e-10	6.10e-02
EA spliceAI_04 AF_1 Exclusive	Somatic Exclusive	4.55e-01	6.74e-01	2.63e-01	3.19e-10
Somatic Exclusive	EA spliceAI_04 AF_1 Exclusive	6.26e-03	4.19e-01	1.46e-09	5.53e-02
EA spliceAI_04 AF_1 Exclusive	Overlap	3.17e-01	8.12e-01	5.15e-01	1.98e-01
Somatic Exclusive	Overlap	1.98e-02	7.13e-01	1.98e-02	1.98e-02
Overlap	Exclusives	5.06e-01	3.10e-02	3.13e-37	2.09e-08



Evaluating how well EA spliceAI_04 AF_1 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_04 AF_1 Exclusive	Somatic	0.84	0.65	-0.11	0.23	6.36
Somatic Exclusive	EA spliceAI_04 AF_1	0.55	-0.18	1.39	1.13	2.24
EA spliceAI_04 AF_1 Exclusive	Somatic Exclusive	0.84	0.54	-0.10	0.28	6.81
Somatic Exclusive	EA spliceAI_04 AF_1 Exclusive	0.55	-0.49	1.24	0.86	2.52
EA spliceAI_04 AF_1 Exclusive	Overlap	0.91	0.92	0.64	0.60	1.34
Somatic Exclusive	Overlap	0.99	1.17	0.65	1.71	1.70
Overlap	Exclusives	0.62	1.14	4.37	1.62	7.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI_04 AF_1 Exclusive	Somatic	0.02	-0.06	0.10	0.56	19.21
Somatic Exclusive	EA spliceAI_04 AF_1	0.01	-0.03	0.97	0.86	1.21
EA spliceAI_04 AF_1 Exclusive	Somatic Exclusive	0.02	-0.06	0.15	0.85	21.83
Somatic Exclusive	EA spliceAI_04 AF_1 Exclusive	0.01	-0.51	0.94	0.35	1.12
EA spliceAI_04 AF_1 Exclusive	Overlap	0.00	0.42	-0.35	-0.12	1.15
Somatic Exclusive	Overlap	0.00	4.22	0.43	28.13	9.63
Overlap	Exclusives	0.02	0.32	6.38	1.93	8.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI_04 AF_1 Exclusive	201	196	TEX52;C16orf86;AP000781.2;CBS;SMIM6
Somatic Exclusive	36	36	
Overlap	1	1