Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI_02 AF_1 Exclusive	familial	3.87e-01	3.51e-01	6.85e-01	1.18e-05
familial Exclusive	spliceAI_02 AF_1	1.12e-05	9.42e-01	1.44e-07	7.60e-01
spliceAI_02 AF_1 Exclusive	familial Exclusive	7.09e-01	1.84e-01	6.80e-01	1.78e-05
familial Exclusive	spliceAI_02 AF_1 Exclusive	2.60e-06	8.73e-01	6.51e-07	7.56e-01
spliceAI_02 AF_1 Exclusive	Overlap	2.18e-01	3.37e-01	2.38e-01	1.98e-01
familial Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.17e-04	1.58e-03	6.59e-04	4.96e-04



Evaluating how well spliceAI_02 AF_1 genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_02 AF_1 Exclusive	familial	0.78	0.45	-0.10	0.08	5.16
familial Exclusive	spliceAI_02 AF_1	0.51	-0.01	-0.17	-0.26	0.38
spliceAI_02 AF_1 Exclusive	familial Exclusive	0.78	0.25	-0.52	0.11	4.49
familial Exclusive	spliceAI_02 AF_1 Exclusive	0.51	-0.26	-0.31	-0.47	0.38
spliceAI_02 AF_1 Exclusive	Overlap	0.88	1.45	1.07	1.44	1.38
familial Exclusive	Overlap	1.00	1.67	1.98	2.05	1.75
Overlap	Exclusives	0.57	0.58	1.65	1.04	3.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_02 AF_1 Exclusive	familial	0.00	-0.06	-0.31	-0.13	9.93
familial Exclusive	spliceAI_02 AF_1	0.01	1.12	1.92	1.10	0.64
spliceAI_02 AF_1 Exclusive	familial Exclusive	0.00	-0.02	-0.45	-0.01	5.45
familial Exclusive	spliceAI_02 AF_1 Exclusive	0.01	-0.34	-0.28	-0.33	-0.13
spliceAI_02 AF_1 Exclusive	Overlap	0.00	0.39	0.28	0.54	-0.07
familial Exclusive	Overlap	0.08	196.58	661.05	391.74	37.27
Overlap	Exclusives	0.02	12.43	7.28	5.18	11.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI_02 AF_1 Exclusive	152	148	AC139530.2;AL024498.2;AC008763.2;AC113554.1
familial Exclusive	22	22	
Overlap	1	1