Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI_02 AF_1	Somatic	3.41e-01	2.13e-01	3.29e-01	1.85e-05
Somatic	spliceAI_02 AF_1	1.56e-03	5.38e-01	7.81e-09	1.98e-01



Evaluating how well spliceAI_02 AF_1 genes are linked to Somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_02 AF_1	Somatic	0.74	-1.61	-2.50	-1.75	5.04
Somatic	spliceAI_02 AF_1	0.51	0.44	0.27	0.09	0.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_02 AF_1	Somatic	0.01	0.17	0.39	0.12	18.24
Somatic	spliceAI_02 AF_1	0.01	-0.24	-0.66	-0.47	-0.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI_02 AF_1	153	149	AC113554.1;AC008763.2;AL024498.2;AC139530.2
Somatic	37	37