Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI_06 AF_1 Z_2 Exclusive	familial	2.54e-01	2.70e-02	6.91e-02	3.56e-04
familial Exclusive	spliceAI_06 AF_1 Z_2	3.14e-08	1.96e-01	1.06e-04	6.37e-01
spliceAI_06 AF_1 Z_2 Exclusive	familial Exclusive	3.16e-01	1.86e-02	2.78e-01	3.47e-04
familial Exclusive	spliceAI_06 AF_1 Z_2 Exclusive	1.50e-08	2.22e-01	1.10e-04	3.36e-01
spliceAI_06 AF_1 Z_2 Exclusive	Overlap	6.77e-01	9.17e-01	3.35e-01	4.88e-01
familial Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-04
Overlap	Exclusives	3.83e-04	2.12e-03	1.49e-18	6.04e-04



Evaluating how well spliceAI_06 AF_1 Z_2 genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_06 AF_1 Z_2 Exclusive	familial	0.72	-0.09	-1.26	-0.49	3.56
familial Exclusive	spliceAI_06 AF_1 Z_2	0.48	-2.30	-1.92	-1.44	-0.42
spliceAI_06 AF_1 Z_2 Exclusive	familial Exclusive	0.73	0.01	-1.42	-0.17	3.21
familial Exclusive	spliceAI_06 AF_1 Z_2 Exclusive	0.48	-2.56	-2.39	-1.67	-0.88
spliceAI_06 AF_1 Z_2 Exclusive	Overlap	0.63	-0.31	-0.34	-1.00	0.60
familial Exclusive	Overlap	0.99	1.75	2.00	2.73	2.26
Overlap	Exclusives	0.56	0.98	-0.12	0.38	2.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI_06 AF_1 Z_2 Exclusive	familial	0.00	-0.81	-2.48	-1.13	2.39
familial Exclusive	spliceAI_06 AF_1 Z_2	0.01	-0.33	-0.06	-0.21	0.21
spliceAI_06 AF_1 Z_2 Exclusive	familial Exclusive	0.00	-0.81	-2.52	-0.77	2.43
familial Exclusive	spliceAI_06 AF_1 Z_2 Exclusive	0.01	-1.63	-1.70	-1.23	-0.72
spliceAI_06 AF_1 Z_2 Exclusive	Overlap	0.00	-0.52	-0.44	-0.90	-0.28
familial Exclusive	Overlap	0.02	2.57	126.19	88.08	18.96
Overlap	Exclusives	0.03	42.17	34.71	9.92	22.86

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI_06 AF_1 Z_2 Exclusive	120	117	AC113554.1;AC139530.2;PRR5-ARHGAP8
familial Exclusive	21	21	
Overlap	2	2