Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA AF_1 Exclusive	familial	8.07e-01	6.04e-01	8.90e-01	6.36e-05
familial Exclusive	EA AF_1	4.62e-08	6.20e-01	3.77e-12	4.48e-01
EA AF_1 Exclusive	familial Exclusive	7.41e-01	2.73e-01	5.94e-01	4.61e-04
familial Exclusive	EA AF_1 Exclusive	7.16e-08	7.55e-01	2.00e-12	4.38e-01
EA AF_1 Exclusive	Overlap	5.94e-01	7.31e-01	8.57e-01	1.11e-01
familial Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.48e-05	3.23e-02	2.36e-20	7.29e-03



Evaluating how well EA AF_1 genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA AF_1 Exclusive	familial	0.78	0.17	-1.10	-0.14	4.87
familial Exclusive	EA AF_1	0.52	-0.43	0.93	0.60	1.05
EA AF_1 Exclusive	familial Exclusive	0.77	0.05	-1.79	-0.41	3.78
familial Exclusive	EA AF_1 Exclusive	0.51	-0.61	0.91	0.27	0.80
EA AF_1 Exclusive	Overlap	0.84	0.77	0.84	0.75	2.03
familial Exclusive	Overlap	1.00	1.89	2.98	2.51	3.24
Overlap	Exclusives	0.55	3.31	1.67	1.56	3.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA AF_1 Exclusive	familial	0.02	2.20	0.79	2.22	27.30
familial Exclusive	EA AF_1	0.02	1.70	2.57	1.84	2.18
EA AF_1 Exclusive	familial Exclusive	0.02	2.31	0.89	2.79	32.36
familial Exclusive	EA AF_1 Exclusive	0.01	-0.09	0.67	0.27	0.61
EA AF_1 Exclusive	Overlap	0.00	0.10	0.26	-0.05	0.13
familial Exclusive	Overlap	0.06	27.77	418.82	180.62	161.70
Overlap	Exclusives	0.02	12.30	7.47	7.63	11.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA AF_1 Exclusive	263	258	CT45A3;AP000781.2;C16orf86;TEX52;CBS
familial Exclusive	20	20	
Overlap	3	3