Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA AF_1	familial	8.26e-01	6.22e-01	5.97e-01	6.62e-05
familial	EA AF_1	6.23e-08	6.55e-01	3.30e-10	6.87e-01



Evaluating how well EA AF_1 genes are linked to familial genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA AF_1	familial	0.78	0.19	-1.20	-0.47	4.93
familial	EA AF_1	0.52	0.35	1.16	0.63	0.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA AF_1	familial	0.02	3.48	0.84	2.14	20.15
familial	EA AF_1	0.01	0.30	1.05	0.30	0.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA AF_1	263	258	TEX52;CT45A3;CBS;AP000781.2;C16orf86
familial	23	23