Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI AF_1 Exclusive	somatic	1.37e-01	3.17e-01	9.59e-02	2.99e-15
somatic Exclusive	EA spliceAI AF_1	2.19e-03	3.72e-02	3.89e-17	4.71e-03
EA spliceAI AF_1 Exclusive	somatic Exclusive	3.38e-01	4.46e-01	1.34e-01	2.24e-13
somatic Exclusive	EA spliceAI AF_1 Exclusive	1.49e-03	2.81e-02	3.10e-16	2.06e-02
EA spliceAI AF_1 Exclusive	Overlap	1.14e-02	1.08e-02	1.27e-02	2.96e-04
somatic Exclusive	Overlap	4.36e-07	5.12e-02	4.36e-07	3.66e-05
Overlap	Exclusives	8.35e-04	2.49e-03	3.85e-42	6.85e-05



Evaluating how well EA spliceAI AF_1 genes are linked to somatic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI AF_1 Exclusive	somatic	0.88	1.73	1.44	1.16	7.47
somatic Exclusive	EA spliceAI AF_1	0.55	1.56	2.08	2.02	3.19
EA spliceAI AF_1 Exclusive	somatic Exclusive	0.87	1.13	1.17	0.98	8.52
somatic Exclusive	EA spliceAI AF_1 Exclusive	0.55	1.68	2.46	2.26	2.32
EA spliceAI AF_1 Exclusive	Overlap	0.96	1.48	2.73	1.41	2.99
somatic Exclusive	Overlap	0.99	2.06	1.89	2.74	3.33
Overlap	Exclusives	0.59	1.05	2.54	1.95	5.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI AF_1 Exclusive	somatic	0.06	3.33	7.97	6.50	96.01
somatic Exclusive	EA spliceAI AF_1	0.02	1.40	2.03	1.90	2.53
EA spliceAI AF_1 Exclusive	somatic Exclusive	0.06	3.66	7.54	5.61	139.41
somatic Exclusive	EA spliceAI AF_1 Exclusive	0.02	1.43	1.92	1.45	1.11
EA spliceAI AF_1 Exclusive	Overlap	0.00	1.42	3.03	1.33	0.09
somatic Exclusive	Overlap	0.01	0.58	4.26	55.40	8.98
Overlap	Exclusives	0.02	3.03	5.44	3.77	7.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI AF_1 Exclusive	278	272	TEX52;AC069368.1;CBS;C16orf86;CT45A3;AP000781.2
somatic Exclusive	34	34	
Overlap	3	3