Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD EA_spliceAI AF_1 Exclusive	AD GS	2.81e-03	1.57e-04	1.67e-05	1.11e-06
AD GS Exclusive	AD EA_spliceAI AF_1	1.13e-01	4.40e-01	4.27e-02	7.99e-02
AD EA_spliceAI AF_1 Exclusive	AD GS Exclusive	7.89e-03	8.18e-04	1.77e-04	2.55e-05
AD GS Exclusive	AD EA_spliceAI AF_1 Exclusive	3.33e-01	8.02e-01	1.09e-01	2.25e-01
AD EA_spliceAI AF_1 Exclusive	Overlap	1.73e-02	8.49e-02	8.03e-03	8.82e-04
AD GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.21e-04	8.04e-05	3.14e-16	9.69e-08



Evaluating how well AD EA_spliceAI AF_1 genes are linked to AD GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD EA_spliceAI AF_1 Exclusive	AD GS	0.79	2.21	4.19	2.84	5.28
AD GS Exclusive	AD EA_spliceAI AF_1	0.56	1.85	0.82	1.73	2.04
AD EA_spliceAI AF_1 Exclusive	AD GS Exclusive	0.76	2.28	3.60	2.30	4.38
AD GS Exclusive	AD EA_spliceAI AF_1 Exclusive	0.54	1.17	0.53	1.19	1.44
AD EA_spliceAI AF_1 Exclusive	Overlap	0.98	1.87	2.64	2.09	2.81
AD GS Exclusive	Overlap	1.00	2.30	2.48	2.35	2.88
Overlap	Exclusives	0.65	5.61	6.08	3.36	5.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD EA_spliceAI AF_1 Exclusive	AD GS	0.01	3.95	7.54	6.65	11.59
AD GS Exclusive	AD EA_spliceAI AF_1	0.01	4.91	8.44	3.76	9.88
AD EA_spliceAI AF_1 Exclusive	AD GS Exclusive	0.00	2.14	4.42	2.75	6.01
AD GS Exclusive	AD EA_spliceAI AF_1 Exclusive	0.01	3.00	2.69	2.60	1.14
AD EA_spliceAI AF_1 Exclusive	Overlap	0.01	11.27	9.32	18.85	18.18
AD GS Exclusive	Overlap	0.06	143.79	229.84	81.80	206.57
Overlap	Exclusives	0.04	45.66	54.48	20.15	28.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD EA_spliceAI AF_1 Exclusive	98	97	RFPL2
AD GS Exclusive	22	22	
Overlap	3	3