Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
fcs_3em_Ad_142 Exclusive	adgs_25_genes	3.44e-13	7.79e-12	4.70e-17	2.13e-15
adgs_25_genes Exclusive	fcs_3em_Ad_142	1.57e-03	1.86e-03	5.05e-07	1.67e-08
fcs_3em_Ad_142 Exclusive	adgs_25_genes Exclusive	2.55e-08	3.91e-08	2.72e-11	3.40e-10
adgs_25_genes Exclusive	fcs_3em_Ad_142 Exclusive	1.39e-02	1.25e-02	2.73e-05	7.53e-08
fcs_3em_Ad_142 Exclusive	Overlap	2.98e-14	5.70e-05	2.98e-14	2.50e-12
adgs_25_genes Exclusive	Overlap	2.98e-14	2.75e-11	2.09e-13	8.95e-11
Overlap	Exclusives	2.28e-08	4.38e-10	4.86e-21	5.42e-16



Evaluating how well fcs_3em_Ad_142 genes are linked to adgs_25_genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_3em_Ad_142 Exclusive	adgs_25_genes	0.91	4.09	7.47	4.28	7.80
adgs_25_genes Exclusive	fcs_3em_Ad_142	0.68	3.05	4.49	3.00	6.95
fcs_3em_Ad_142 Exclusive	adgs_25_genes Exclusive	0.88	3.99	5.72	4.31	5.61
adgs_25_genes Exclusive	fcs_3em_Ad_142 Exclusive	0.66	2.74	3.63	2.52	6.77
fcs_3em_Ad_142 Exclusive	Overlap	1.00	3.84	4.13	3.64	4.55
adgs_25_genes Exclusive	Overlap	1.00	3.57	3.82	3.54	3.86
Overlap	Exclusives	0.73	5.52	7.31	3.67	9.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
fcs_3em_Ad_142 Exclusive	adgs_25_genes	0.05	42.92	68.07	66.53	113.91
adgs_25_genes Exclusive	fcs_3em_Ad_142	0.04	23.66	20.76	29.24	46.66
fcs_3em_Ad_142 Exclusive	adgs_25_genes Exclusive	0.02	17.39	31.60	25.47	48.32
adgs_25_genes Exclusive	fcs_3em_Ad_142 Exclusive	0.02	11.89	13.62	13.01	22.01
fcs_3em_Ad_142 Exclusive	Overlap	0.07	136.18	57.05	166.42	118.15
adgs_25_genes Exclusive	Overlap	0.12	397.20	423.17	342.65	258.44
Overlap	Exclusives	0.07	55.63	65.87	49.63	73.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
fcs_3em_Ad_142 Exclusive	136	136	
adgs_25_genes Exclusive	19	19	
Overlap	6	6