Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD EA spliceAI AF_1 Exclusive	GS	7.21e-07	4.43e-07	1.02e-07	1.07e-07
GS Exclusive	AD EA spliceAI AF_1	4.35e-02	2.87e-01	1.20e-02	5.48e-02
AD EA spliceAI AF_1 Exclusive	GS Exclusive	1.33e-04	1.39e-04	3.16e-05	3.46e-05
GS Exclusive	AD EA spliceAI AF_1 Exclusive	1.75e-01	5.05e-01	7.29e-02	1.03e-01
AD EA spliceAI AF_1 Exclusive	Overlap	6.04e-07	2.74e-08	1.28e-07	6.40e-08
GS Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	3.96e-04	1.64e-03	1.79e-17	9.51e-05



Evaluating how well AD EA spliceAI AF_1 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD EA spliceAI AF_1 Exclusive	GS	0.84	3.39	6.23	3.82	5.43
GS Exclusive	AD EA spliceAI AF_1	0.58	2.42	1.89	2.04	3.09
AD EA spliceAI AF_1 Exclusive	GS Exclusive	0.82	3.24	5.27	3.02	5.13
GS Exclusive	AD EA spliceAI AF_1 Exclusive	0.57	2.63	1.35	1.94	2.57
AD EA spliceAI AF_1 Exclusive	Overlap	0.99	2.72	2.91	2.99	3.56
GS Exclusive	Overlap	1.00	2.76	3.21	2.80	3.60
Overlap	Exclusives	0.64	3.50	5.24	3.56	5.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD EA spliceAI AF_1 Exclusive	GS	0.02	24.02	41.01	33.49	41.68
GS Exclusive	AD EA spliceAI AF_1	0.02	20.59	13.98	10.62	21.28
AD EA spliceAI AF_1 Exclusive	GS Exclusive	0.01	18.68	29.98	18.75	12.79
GS Exclusive	AD EA spliceAI AF_1 Exclusive	0.01	8.23	7.24	6.44	9.35
AD EA spliceAI AF_1 Exclusive	Overlap	0.02	22.91	43.54	20.04	56.75
GS Exclusive	Overlap	0.09	238.27	236.19	179.00	139.55
Overlap	Exclusives	0.06	35.36	75.12	40.15	77.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD EA spliceAI AF_1 Exclusive	110	109	RFPL2
GS Exclusive	21	21	
Overlap	4	4