Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA spliceAI AF_0001 Exclusive	GS	5.93e-01	5.40e-01	3.14e-01	5.13e-03
GS Exclusive	EA spliceAI AF_0001	5.37e-02	7.12e-01	2.16e-01	5.29e-01
EA spliceAI AF_0001 Exclusive	GS Exclusive	7.23e-01	8.48e-01	4.16e-01	1.08e-02
GS Exclusive	EA spliceAI AF_0001 Exclusive	2.39e-02	3.73e-01	2.26e-01	8.42e-01
EA spliceAI AF_0001 Exclusive	Overlap	7.31e-01	4.58e-01	1.41e-01	2.82e-01
GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.38e-03	1.78e-03	9.17e-04	7.58e-04



Evaluating how well EA spliceAI AF_0001 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI AF_0001 Exclusive	GS	0.64	-0.06	0.65	0.25	2.77
GS Exclusive	EA spliceAI AF_0001	0.53	-0.79	0.07	0.19	0.74
EA spliceAI AF_0001 Exclusive	GS Exclusive	0.64	-0.09	0.38	0.26	2.37
GS Exclusive	EA spliceAI AF_0001 Exclusive	0.51	-1.57	-0.73	-0.65	0.24
EA spliceAI AF_0001 Exclusive	Overlap	0.65	0.18	0.73	0.90	0.83
GS Exclusive	Overlap	1.00	2.90	2.99	3.15	3.13
Overlap	Exclusives	0.61	1.75	3.36	2.27	3.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA spliceAI AF_0001 Exclusive	GS	0.00	-0.38	-0.66	-0.47	0.18
GS Exclusive	EA spliceAI AF_0001	0.01	11.67	5.79	5.44	19.89
EA spliceAI AF_0001 Exclusive	GS Exclusive	0.00	-0.61	-0.55	-0.27	0.18
GS Exclusive	EA spliceAI AF_0001 Exclusive	0.00	-0.53	-0.23	-0.22	0.74
EA spliceAI AF_0001 Exclusive	Overlap	0.00	-0.33	-0.21	-0.16	-0.14
GS Exclusive	Overlap	0.19	513.46	775.78	833.72	154.33
Overlap	Exclusives	0.04	42.92	21.73	26.73	54.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA spliceAI AF_0001 Exclusive	71	70	TMEM269
GS Exclusive	22	22	
Overlap	3	3