Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AD spliceAI AF_1	GS	9.45e-05	4.71e-05	2.47e-05	9.17e-07
GS	AD spliceAI AF_1	3.81e-01	1.34e-01	7.97e-02	7.43e-02



Evaluating how well AD spliceAI AF_1 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD spliceAI AF_1	GS	0.82	3.25	5.20	2.76	5.19
GS	AD spliceAI AF_1	0.60	2.20	1.94	1.64	2.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AD spliceAI AF_1	GS	0.00	5.96	8.93	3.94	6.12
GS	AD spliceAI AF_1	0.00	2.68	2.84	3.76	2.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AD spliceAI AF_1	56	54	AC010326.2;AL132671.2
GS	25	25