Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
spliceAI 0001 05_rand	GeneGroup2	6.41e-04	6.56e-05	1.33e-05	3.92e-07
GeneGroup2	spliceAI 0001 05_rand	5.95e-01	2.81e-01	1.21e-01	2.78e-02



Evaluating how well spliceAI 0001 05_rand genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI 0001 05_rand	GeneGroup2	0.79	2.45	5.49	2.30	5.02
GeneGroup2	spliceAI 0001 05_rand	0.61	1.24	1.85	1.07	2.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
spliceAI 0001 05_rand	GeneGroup2	0.00	2.49	6.58	1.93	5.23
GeneGroup2	spliceAI 0001 05_rand	0.01	3.75	3.45	2.53	4.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
spliceAI 0001 05_rand	58	56	AC008763.2;KBTBD11-OT1
GeneGroup2	25	25